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Real members of MyEndometrialCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I was diagnosed with Stage 1B Grade 1 endometrioid endometrial cancer in 2025. I had a hysterectomy followed by 3 rounds of vaginal brachytherapy. Less than a year later, I had a recurrence in my left ischial bone (sit bone), and my biopsy showed ER 90% and PR 90% positive cancer. I also have small lung nodules being monitored.

My oncologist recommended chemotherapy and immunotherapy, but because my cancer is strongly hormone-positive, I asked if I could try hormone therapy first. I recently… read more

July 19
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A MyEndometrialCancerTeam Member

Amanda, I'm delighted to hear you have been able to continue to work. Getting different opinions from my doctors on that.

July 26
A MyEndometrialCancerTeam Member

I’ve continued to work, although there have definitely been some really hard days. Over the past month and a half, taking tramadol, meloxicam, and Tylenol has made a big difference, and my pain has improved quite a bit.

I do have an appointment on July 31 with my radiation oncologist to discuss and schedule radiation. It’s encouraging to hear that radiation helped your pain so much, and it gives me hope. Thank you for taking the time to respond I really appreciate it.

July 19
A MyEndometrialCancerTeam Member

I too have metastasis to my “sit bones” I had such extreme pain I had to quit working and I eventually had to have surgery on my hip. II found radiation extremely helpful for the pain. I would recommend it if you are in pain.

July 19
myEndometrialCancerTeam

What a thoughtful and informed approach to your own care — advocating for hormone therapy first given such strong receptor positivity makes a lot of sense, and it's great that your oncologist was open to exploring that with you.

While there aren't widely shared member stories specifically about alternating Megace and Show Full Answer

What a thoughtful and informed approach to your own care — advocating for hormone therapy first given such strong receptor positivity makes a lot of sense, and it's great that your oncologist was open to exploring that with you.

While there aren't widely shared member stories specifically about alternating Megace and tamoxifen before chemotherapy, this combination is a recognized hormone therapy approach for recurrent endometrial cancer, particularly when cancer tests strongly positive for estrogen and progesterone receptors, as yours does. Here's a quick overview of how these two treatments work:

- Megace (megestrol acetate) is a progestin — one of the most commonly used hormone therapies for endometrial cancer. It works by slowing cancer cell growth
- Tamoxifen is a selective estrogen receptor modulator (SERM) that blocks estrogen from reaching cancer cells

Alternating them is sometimes used to try to maintain sensitivity to each drug, since using one continuously can sometimes reduce its effectiveness over time. Some things worth keeping in mind as you move forward:

- Hormone therapy side effects can include bloating, weight gain, hot flashes, and vaginal dryness
- Your oncologist's recommendation of chemotherapy and immunotherapy remains on the table if hormone therapy doesn't achieve the desired response
- The lung nodules being monitored make it especially important to have regular check-ins with your care team to track any changes

Your strong ER/PR positivity (90%/90%) is actually a hopeful sign that hormone therapy could be effective for you. Staying closely connected with your oncologist as you monitor your response is really key.

July 19

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