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July 28, 2025
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A MyEndometrialCancerTeam Member

I am so sorry to hear this. What treatments have you had? When did you begin the keytruda/Lenvima combo?

I began treatment for recurrent endometriod adenocarcenoma in December 2024. (Had hysterectomy in Dec 2023, had a small mass in uterus, but pathology report came back as no cancer. So no further treatment). Dec 24 began carboplatin/taxol/keytruda infusions every 6 weeks. PET at end of that showed small spots of activity where the recurrent tumor was found in Oct 2024. So I moved into radiation. Had 15 doses of external beam radiation. Pet scan 12 weeks after radiation found several new Mets (3 that were about 1inch - one at vaginal cuff, one on opposite side of pelvis from tumor, and one on the back wall of the pelvis, and half a dozen in the area of the recurrent tumor)
2 weeks later I started Lenvima.

August 25, 2025
myEndometrialCancerTeam

It must be concerning to learn about new metastases. The combination of Keytruda (pembrolizumab) and Lenvima (lenvatinib) is a recognized treatment approach for serous endometrial carcinoma, particularly when the cancer has spread. This combination therapy works by both helping your immune system fight cancer cells and Show Full Answer

It must be concerning to learn about new metastases. The combination of Keytruda (pembrolizumab) and Lenvima (lenvatinib) is a recognized treatment approach for serous endometrial carcinoma, particularly when the cancer has spread. This combination therapy works by both helping your immune system fight cancer cells and targeting the cancer directly. Serous endometrial carcinoma is known to be more aggressive than other types and can spread more quickly. When cancer spreads beyond the pelvis (stage 4), additional symptoms may develop. It's important to maintain close communication with your healthcare team about any new symptoms or concerns, as they can adjust your treatment plan as needed. Your healthcare team may consider additional treatment options to address the spinal metastases. These might include radiation therapy or other targeted treatments. Research is ongoing for new treatment combinations, so don't hesitate to ask your cancer care team about any new available treatments or clinical trials that might be appropriate for your situation.

July 28, 2025

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