It sounds like you're asking about CA-125 levels changing during chemotherapy for stage 4 endometrial cancer - dropping from 350 to 30 after 7 rounds, but then rising to 69?
Fluctuating tumor markers can be concerning, especially after they initially responded well to treatment. A rise in CA-125 after it decreased could Show Full Answer
It sounds like you're asking about CA-125 levels changing during chemotherapy for stage 4 endometrial cancer - dropping from 350 to 30 after 7 rounds, but then rising to 69?
Fluctuating tumor markers can be concerning, especially after they initially responded well to treatment. A rise in CA-125 after it decreased could suggest several things, though only your oncologist can interpret what this means for your specific situation.
For stage 4 endometrial cancer, treatment often involves combination chemotherapy. The most common regimen includes paclitaxel plus doxorubicin with either carboplatin or cisplatin. When cancer progresses or recurs, doctors may adjust the treatment approach.
Your care team might consider:
- Continuing or adjusting chemotherapy
- Adding immunotherapy (like pembrolizumab or dostarlimab)
- Hormone therapy
- Targeted therapy
- Clinical trials investigating new treatments
Given the weight (100 lbs at 82 years old), it's important to discuss how treatment is affecting overall health and quality of life. Your oncologist can help balance aggressive treatment with maintaining strength and managing side effects.
This is definitely something to discuss with your cancer care team at the next appointment. They can order additional imaging or tests to understand what the rising marker means and recommend next steps.
December 19, 2025
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