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Real members of MyEndometrialCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyEndometrialCancerTeam Member asked a question 💭
Nye, MT

In 2017 I was diagnosed with uterine serous cancer stage 1, grade3. In 2024 I had a recurrence and the rumor metastasized to my sigmoid colon and external iliac lymph node. I am 80 years old.My oncologist did not recommend surgery. I had six rounds of chemo, carbo, taxol and trastuzamob. The treatment seemed to work and the tumor on my colon shrunk but did not disappear. The iliac lymph node shrunk. My tumor is very HER 2 POSITIVE. I continued with about 10 months of trastuzamob every three… read more

December 19, 2025
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myEndometrialCancerTeam

Has anyone else experienced endometrial cancer that spread to the colon and had surgery?

Endometrial cancer spreading to the colon is indeed rare. While the search results don't include specific member experiences with colon surgery for metastatic endometrial cancer, the information confirms that spread to the rectum and Show Full Answer

Has anyone else experienced endometrial cancer that spread to the colon and had surgery?

Endometrial cancer spreading to the colon is indeed rare. While the search results don't include specific member experiences with colon surgery for metastatic endometrial cancer, the information confirms that spread to the rectum and bowel area is uncommon.

When endometrial cancer does spread to the bowel, symptoms can include constipation, diarrhea, and blood in stool. Some reports note that most people with cancer spread to the rectum also have endometriosis, where uterine tissues grow outside the uterus.

Getting a second opinion is a wise step, especially given your unique situation. Your oncologist's concerns about quality of life after colon resection surgery are valid considerations, particularly regarding the potential need for an ostomy bag.

Since your cancer is HER2 positive and responded initially to targeted therapy, switching to Enhertu (which also targets HER2) could be a reasonable option to explore. A second opinion can help you weigh the risks and benefits of surgery versus continuing with targeted medication.

Given how rare this specific metastasis pattern is, connecting with others who've faced similar decisions might be challenging, but your medical team's expertise with your individual case will be most valuable in making this decision.

December 19, 2025

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