I was given Keytruda and Lenvemia for my treatment and my doctor said never again as it gave me 4 months of pneumonia and on oxygen at home with also 4 months of prednisone! Never again!’

Is your Mom able to exercise? 150 minutes of HITT exercise a week along with 20 minutes of weight lifting 3x/week helps with metasis. Any exercise is helpful.
Is she keeping her carbohydrate level low, no processed carbs?
How is her blood sugar level? Does she meditate, pray, or do other activities to lower anxiety. Anxiety does not allow the body to heal. Is she focused on sleeping well?
My theory with high grade cancer is you cannot rely on the drugs alone. Look for a copy of Radical Remission by Dr Kelly Turner, you can find used copies on ebay. Plenty of people go beyond treatment and become survivors, not sure you can get there with treatment alone. In the short term you can look for Youtube videos on the subject to direct you in the healing direction.
Your Mom is lucky to have you in her corner. It helps to have another brain working for you when you are dealing with chemo brain.
Sending you and your Mom prayers for peace and healing.

Hi. Your mom can survive. There is not a “ medical cure “, but there are more weapons in the arsenal to prolong living with cancer. I also have p53 mutation and pdl1 neg. I was going to be on Lenvima and Keytruda, but my oncologist offered a trial drug, Azenosertib. It worked in shrinking tumors in my chest. There is hope . God bless you and your mother 🤗

Thanks

* Primary Diagnosis: High-Grade Endometrial Carcinoma (Uterine Cancer), initially staged as Stage 3C.
* Prior Treatments: Completed a total hysterectomy (surgical removal of the uterus), followed by 6 cycles of intravenous chemotherapy and local pelvic radiation therapy (completed in April 2025).
* Current Disease Status (Based on PET/CT dated 13-May-2026): Showed features of regional disease progression. The recurrence is strictly localized and regional, confined entirely to two areas inside the lower pelvis (the external and internal iliac lymph nodes). One node remains stable, while a new hypermetabolic (highly active) node appeared on the right side.
* Organ Status: 0% distant spread. There is absolutely no metabolic activity or recurrence in her original surgical bed, lungs, liver, bones, or brain. Her vital organs are completely clean and healthy.
* Current Regimen: Actively taking a systemic hormone barrier treatment: Megacet 40 (Megestrol Acetate), 3 tablets daily (120 mg/day), split on a strict 8-hour schedule to lock down node growth.

🧬 Molecular Biomarker Profile & Clinical Significance
Her tumor tissue block was analyzed for genetic alterations. Her molecular map contains a unique combination of growth accelerators and specific actionable targets:
1. Actionable Therapeutic Targets (The Vulnerabilities)

* ✅ PTEN Mutation & ✅ PIK3CA Mutation: These two mutations control the PI3K/Akt/mTOR cellular growth pathway. In her tumor, they act like a stuck accelerator pedal forcing cells to multiply. However, in modern oncology, this is an excellent advantage. If her current hormone treatment ever needs a backup, doctors can use oral mTOR inhibitors (such as Everolimus), which act like a precise key designed to shut down this exact mutation pathway.

2. Aggressive Tumor Indicators (The Challenges)

* ⚠️ TP53 Mutation & High-Grade Status: A TP53 abnormality means the tumor lacks its natural cellular "brakes" to fix damaged DNA, explaining why the cells are high-grade and why they mutated past her initial chemotherapy. Knowing this allows her doctors to completely bypass standard chemotherapies and look directly at advanced targeted options.
* ⚠️ PD-L1 Negative: This indicates that the tumor has low expression of the specific protein targeted by basic, single-agent immunotherapies.

3. Standard Next-Line Clinical Backup Options
Because she is PD-L1 negative and has a TP53 mutation, if her upcoming August scan shows she needs to switch from Megacet 40, global guidelines (such as NCCN protocols) point directly to the combination of Lenvatinib plus Pembrolizumab (Keytruda). Lenvatinib works by cutting off the blood vessels to those two pelvic nodes, which effectively "unmasks" the cells and forces her immune system to destroy them despite the negative PD-L1 status
will my mom survive