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Diagnosis was Stage IIC Mixed Endometrioid and Serous Endometrial Adenocarcinoma. Treatment included complete hysterectomy- chemo 6 rounds Taxol and Carboplatin; 28 rounds External Beam Radiation. Original Biopsy showed only Endometrioid Cancer; pelvic washings showed the Serous Cancer - so Chemo and Radiation were added to treatment plan. Considering trial of HRT possibly - would like to hear from those who have please.

July 27
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A MyEndometrialCancerTeam Member

That’s good advice really. I know it’s frustrating. I’m going to be 67 in December and I know some of this is age and less activity for me . But who knows what all these treatments do to our metabolism and hormones. I only know that I’m alive and “ healthy “ for a woman who has had 3 recurrences of this cancer. For that I’m extremely thankful. 🥲

August 14
A MyEndometrialCancerTeam Member

Thanks Christine! Yes I’m just trying to stay positive. At least I’m much stronger with continued exercise but still struggling with weight loss despite being more active. My sleep is not back to normal yet and I know this can greatly sabotage weight loss so focussing on that as well. Still being told that my body has been through a lot and that I need to be patient.

August 13
A MyEndometrialCancerTeam Member

Hi BD. I had similar experience. Have serous EC. Since treatments I’ve gained 20 lbs. weight gain from Decadron steroid administered before my trial drug Azenosertib. Can’t get weight off / I’m still on drug but thankfully Not on the steroid! Have had chemo Rad, immunotherapy, and Tamoxifen! The one I didn’t continue with was Tamoxifen due to side effects
But everyone is different! I dont sweat the wt gain anymore. Best of care to you 🤗

July 29
A MyEndometrialCancerTeam Member

Thanks!!

July 27
myEndometrialCancerTeam

What a journey — a complete hysterectomy, 6 rounds of chemo, and 28 rounds of external beam radiation is a lot for your body to go through. It's completely understandable that weight management feels frustrating, especially when you're already doing so much right with weight training and a good diet.

Weight gain after Show Full Answer

What a journey — a complete hysterectomy, 6 rounds of chemo, and 28 rounds of external beam radiation is a lot for your body to go through. It's completely understandable that weight management feels frustrating, especially when you're already doing so much right with weight training and a good diet.

Weight gain after treatment for endometrial cancer is very common. Here's why it can be stubborn:

- Treatment-induced menopause from a hysterectomy shifts hormones dramatically, slowing metabolism
- Chemotherapy can cause fluid retention and metabolic changes
- Radiation to the pelvis can affect how your body processes and stores fat
- Steroid medications often given alongside chemo can contribute to weight gain that lingers

Since you're already active and eating well, the hormonal shift from surgical menopause is likely a big factor. This is also why HRT comes up as a consideration — it can help address some of these metabolic changes. Regarding HRT after endometrial cancer — this is genuinely a nuanced conversation to have with your oncologist, particularly given your serous component. Serous endometrial cancer is considered higher grade, and some oncologists are more cautious about HRT in this context. It's not a blanket "no," but it does require a very personalized risk-benefit discussion with your care team.

Some MyEndometrialCancerTeam members have explored HRT after treatment and found it helpful for managing surgical menopause symptoms, while others were advised against it depending on their specific cancer type and stage. Hearing those experiences directly from the community could be really valuable as you prepare questions for your doctor.

A few practical tips that may help with weight management alongside what you're already doing:

- Talk to your oncologist or a registered dietitian who specializes in oncology nutrition
- Ask about a referral to an endocrinologist to check hormone and thyroid levels, as both can affect weight post-treatment
- Be patient with your body — hormonal recalibration after this level of treatment can take time, even beyond a year

You're clearly doing a lot of things right. Keep advocating for yourself! 💪

July 27

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