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A MyEndometrialCancerTeam Member asked a question πŸ’­
Grayson, GA

I received a supplemental report on HER2 protein analysis immunohistochemistry:
HER2 result: Negative (score 1+)

Not sure what this means.. I have my post Op on Monday and should get the surgical pathology results that will tell me the stage.

August 7
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A MyEndometrialCancerTeam Member

Thank you so much Kathleen. I appreciate your good wishes. God bless you and may He continue to keep you in His loving care!

August 9
A MyEndometrialCancerTeam Member

Hi Angie:
It appears from what the Ai answer to your question is right in. My pathology report showed that I was HER 2 positive 3 which I was told meant that it was a more aggressive and recurring cancer but the good news is that it meant I was a good candidate for the Kanjinti targeted therapy mono clonal antibody treatment that started when I started my chemo treatments in the fall of 2023 about 6 weeks after my hysterectomy, stayed on the every 3 week infusions for 2 years (a year more than most people are on it because I was able to tolerate it and because I was not a candidate for brachytherapy due to a deviated septum near the top of my vagina).

This 9/11 will be 3 years since my hysterectomy and I am doing well.

May thatch give you some hope as you move forward in your journey to not only being a cancer survivor but to being a thriver.

I will pray for your upcoming post surgery appointment with your oncologist and for your course of treatment to go well and give you many many years of enjoying life.
Kathy

August 9
myEndometrialCancerTeam

What does a HER2 Negative score of 1+ mean in an endometrial cancer pathology report?

HER2 is a protein that can appear on cancer cells. When your report says "Negative (score 1+)", it means there is only a very small amount of HER2 protein detected on your cancer cells β€” essentially considered negative.

HER2 scores are Show Full Answer

What does a HER2 Negative score of 1+ mean in an endometrial cancer pathology report?

HER2 is a protein that can appear on cancer cells. When your report says "Negative (score 1+)", it means there is only a very small amount of HER2 protein detected on your cancer cells β€” essentially considered negative.

HER2 scores are measured on a scale:
- 0 – No protein detected
- 1+ – Very low/trace amount (still considered negative)
- 2+ – Borderline (requires further testing)
- 3+ – High levels (considered HER2-positive) A negative HER2 result means that targeted therapies specifically designed for HER2-positive cancers, like trastuzumab, would likely not be part of your treatment plan.

The good news is that HER2-negative results are generally associated with a more favorable prognosis compared to HER2-positive results.

Your post-op appointment on Monday will give you the full picture with surgical staging, which will help your care team map out next steps. It's completely normal to feel overwhelmed by these reports β€” bring all your questions to that appointment! πŸ’™

August 7

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A MyEndometrialCancerTeam Member asked a question πŸ’­
Brookville, IN