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Real members of MyEndometrialCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyEndometrialCancerTeam Member asked a question 💭
Venice, FL
September 4
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That's quite a unique combination — Stage 4B with a Grade 1 tumor. While it's not commonly discussed, it's not impossible. Grade 1 means the tumor cells still look fairly close to normal and are considered less aggressive, which is generally a more hopeful sign even at an advanced stage.

Stage 4B means the cancer has Show Full Answer

That's quite a unique combination — Stage 4B with a Grade 1 tumor. While it's not commonly discussed, it's not impossible. Grade 1 means the tumor cells still look fairly close to normal and are considered less aggressive, which is generally a more hopeful sign even at an advanced stage.

Stage 4B means the cancer has spread beyond the pelvis to areas like:

- Inguinal (groin) lymph nodes
- The upper abdomen
- The omentum (fatty tissue covering abdominal organs)
- Other distant organs Having a Grade 1 tumor at Stage 4B could mean the cancer is spreading slowly, which may influence how your care team approaches treatment. Treatment options at Stage 4B can include:

- Chemotherapy
- Radiation therapy
- Hormone therapy
- Immunotherapy
- Targeted therapy

It's worth having a detailed conversation with your oncologist about how your tumor grade specifically affects your treatment plan and prognosis. Biomarker testing may also be recommended to help personalize your treatment options.

While experiences shared by other MyEndometrialCancerTeam members with this exact combination aren't available here, connecting with others in the community who have Stage 4 or Grade 1 diagnoses separately may still offer valuable insight and support.

September 4

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