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Real members of MyEndometrialCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone taken Keytruda and Lenvima for metastatic endometrial cancer that has not responded to chemotherapy? What was your experience?

A MyEndometrialCancerTeam Member asked a question 💭
Aurora, CO
June 1
 · 
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A MyEndometrialCancerTeam Member

That is very encouraging. Thank you very much!!

June 5
A MyEndometrialCancerTeam Member

Hi Donna. I’ve had recurrent metastatic endometrial cancer. Long story short…after exhausting all of the traditional chemo treatments, radiation (3 times, different sites) and 2 surgeries (different sites) I was at my last option for hope. I was given Keytruda every 3 weeks for 2 years with very minimal side effects. A slight leg rash in the beginning of treatment that went away fairly quickly. I would need a nap every now and then on an occasional day, but really, that was about it. It has now been a year and three months since my last Keytruda infusion and my oncologist just told me that I am in complete remission. I hope you find my message inspiring. God bless you on your journey. ❤️

June 5
myEndometrialCancerTeam

While personal experiences from MyEndometrialCancerTeam members aren't available here right now, there is solid information about this combination that may be helpful.

Keytruda (pembrolizumab) and Lenvima (lenvatinib) are used together specifically for people whose endometrial cancer has worsened after previous treatment Show Full Answer

While personal experiences from MyEndometrialCancerTeam members aren't available here right now, there is solid information about this combination that may be helpful.

Keytruda (pembrolizumab) and Lenvima (lenvatinib) are used together specifically for people whose endometrial cancer has worsened after previous treatment and cannot be treated with surgery or radiation. This combination is particularly relevant when the cancer does not have the dMMR or MSI-H biomarkers. Here's a quick breakdown of how this combination works:

- Keytruda blocks proteins that stop the immune system from attacking cancer cells
- Lenvima targets proteins that cancer cells use to grow and also cuts off the blood supply that helps tumors grow
- Together, they work on two different fronts to fight the cancer

Before starting, your oncologist will test your cancer cells for specific biomarkers (dMMR, MSI-H) to determine the best treatment approach for your specific situation.

As with all treatments, side effects are possible, so it's really important to have an open conversation with your care team about what to expect and how to manage them.

June 1

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