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A MyEndometrialCancerTeam Member asked a question 💭
Niantic, CT

I had a radical hysterectomy. I now have an endometrial origin cancer mass. I have had four chemotherapy treatments and was started on immunotherapy at the last chemo. My mass is shrinking and there is talk of surgery if the mass has shrunk enough around a main artery near my appendicitis. Im wondering if anyone has had something similar and how are dealing with both treatments at the same time?

September 14
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A MyEndometrialCancerTeam Member

The Power of Prayer and the Peace it brings is such a reminder to me of God’s Faithfulness…”Great is His Faithfulness” whether it be with God here on earth or spending Eternity with God.

September 17
myEndometrialCancerTeam

It's really encouraging to hear that your mass is shrinking — that's a meaningful sign that the treatment is working! Combining chemotherapy with immunotherapy is an increasingly common approach for advanced or recurrent endometrial cancer, and many MyEndometrialCancerTeam members have navigated this same path.

The Show Full Answer

It's really encouraging to hear that your mass is shrinking — that's a meaningful sign that the treatment is working! Combining chemotherapy with immunotherapy is an increasingly common approach for advanced or recurrent endometrial cancer, and many MyEndometrialCancerTeam members have navigated this same path.

The combination is used because studies show it can improve how long people live without their cancer progressing. Common drugs used together include:

- Carboplatin + paclitaxel (chemotherapy)
- Pembrolizumab (Keytruda), dostarlimab (Jemperli), or durvalumab (Imfinzi) (immunotherapy) Managing side effects from both treatments at once can feel like a lot. Common side effects to watch for include:

- From chemo: Hair loss, nausea, mouth sores, fatigue
- From immunotherapy: Fever, rashes, joint pain, diarrhea, weakness

In rare cases, immunotherapy can cause more serious reactions, so always flag anything unusual to your care team right away. The possibility of surgery after shrinkage is called neoadjuvant chemotherapy — using treatment first to make a tumor more operable. That's a really hopeful direction!

Sharing your experience on MyEndometrialCancerTeam would likely resonate with many members going through similar treatment journeys. You're definitely not alone in this.

September 14
A MyEndometrialCancerTeam Member

Hi Marjorie....I had six cycles of carboplatin & Taxol with Keytruda (followed by radiation). During that time, I had problems with white counts, platelets, etc as well as new onset thyroid issues. This caused some of my treatments to be held until the blood counts, etc came up. After those cycles, I was scheduled to take Keytruda every six weeks for 2 years. I had one of those infusions and the immunotherapy had to be stopped. Also, along with the new thyroid issues, I developed a bad case of Bell's palsy. Both hypothyroid & Bell's Palsy were felt to be autoimmune adverse effects from Keytruda. So....they held further infusions of Keytruda. I rec'd my last chemo, in May 2025 and June 2025 was my last infusion of immunotherapy. So far, no evidence of disease! Thank you, Lord! By the way, I am Stage 3C1. Best wishes that you are able to take immunotherapy with NO issues!

October 22 (edited)
A MyEndometrialCancerTeam Member

Yes we are Robin 🥰

September 17
A MyEndometrialCancerTeam Member

This only my second round, so far I think it is going well. Day 2 after, I feel like a wet rag. That first week after, I am really slow and tired. As the days go on more energy comes. Good luck and prayers going up! We are in this together! 🙏🏽🫂

September 16

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A MyEndometrialCancerTeam Member asked a question 💭
San Antonio, TX