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Real members of MyEndometrialCancerTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone used letrozole plus everolimus or letrozole plus abemaciclib for treatment of Recurrent Endomentiral Cancer?

A MyEndometrialCancerTeam Member asked a question 💭
Auburn, AL

Brief summary of my history is below:

2018: Diagnosed with FIGO grade 2 endometrioid adenocarcinoma, pT1bN0, MMR-proficient/MSI-stable
2018: Surgery followed by three cycles of carboplatin/paclitaxel and vaginal brachytherapy
November 2021: Recurrence involving the inguinal and iliac lymph nodes, liver surface and lung
2022: Carboplatin, paclitaxel and pembrolizumab; pembrolizumab was discontinued after suspected immune-mediated nephritis caused acute renal failure requiring hospitalization, one… read more

September 25 (edited)
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myEndometrialCancerTeam

What a journey — and what a thoughtful, detailed history. It's clear a lot has been navigated already, and asking about letrozole combinations shows real engagement with exploring next steps.

While no specific member experiences with letrozole plus everolimus or letrozole plus abemaciclib have been shared here, these Show Full Answer

What a journey — and what a thoughtful, detailed history. It's clear a lot has been navigated already, and asking about letrozole combinations shows real engagement with exploring next steps.

While no specific member experiences with letrozole plus everolimus or letrozole plus abemaciclib have been shared here, these combinations are being investigated for recurrent endometrial cancer, particularly for hormone receptor-positive cases. They fall under the category of targeted/hormone therapy combinations.

Given the treatment history — especially the prior pembrolizumab discontinuation due to kidney complications — any new treatment discussion with an oncologist would need to carefully weigh kidney function and prior toxicities. A few things worth raising with an oncologist given this specific situation:

- Biomarker status — MMR-proficient/MSI-stable status limits some immunotherapy options, making hormone-based and targeted combinations more relevant to explore
- Clinical trials — These combinations may be available through trials, which could be worth investigating given the number of prior lines of treatment
- Renal history — Prior kidney complications mean any new regimen needs careful monitoring and dosing consideration

Connecting with a gynecologic oncologist who specializes in recurrent disease, or seeking a second opinion at a major cancer center, could open doors to emerging options like these combinations.

September 25

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