My doctor reduced the dosage of paclitaxol by 20% after the first infusion bc the neuropathy in my feet was so debilitating.
December 30, 2025
What are the side effects of Keytruda maintenance therapy, and how can chemotherapy-induced neuropathy in the feet be managed?
Common side effects of Keytruda (pembrolizumab) include:
* Fatigue
* Musculoskeletal pain
* Rash
* Diarrhea
* Fever
* Cough
* Decreased appetite
* Itching
* Shortness of breath
* Constipation
* Show Full Answer
What are the side effects of Keytruda maintenance therapy, and how can chemotherapy-induced neuropathy in the feet be managed?
Common side effects of Keytruda (pembrolizumab) include:
* Fatigue
* Musculoskeletal pain
* Rash
* Diarrhea
* Fever
* Cough
* Decreased appetite
* Itching
* Shortness of breath
* Constipation
* Nausea
More serious but rare side effects can occur when the immune system attacks healthy organs, including lung inflammation, bowel inflammation, liver problems, and hormone gland issues.
Regarding the neuropathy in your feet, this is a known long-term side effect from certain chemotherapy drugs like cisplatin and paclitaxel. Neuropathy typically causes numbness, tingling, or pain in the hands and feet.
It's really important to discuss this worsening neuropathy with your cancer care team. They can monitor how it's affecting you and help manage the symptoms. Proper treatment can prevent side effects from getting worse, so don't hesitate to bring this up at your next appointment or call sooner if the pain is significantly impacting your daily life.
December 30, 2025
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